A US missile strike on an airbase in central Syria early on Friday was "foolish and irresponsible," President Bashar Assad's office said.
"What America did is nothing but foolish and irresponsible behaviour, which only reveals its short-sightedness and political and military blindness to reality," a statement said.
The US fired a barrage of 59 cruise missiles at the Shayrat base in response to a suspected chemical attack on a rebel-held town on Tuesday widely blamed on the Damascus regime.
The Syrian government has categorically denied the accusation, saying it had struck an arms depot belonging to a jihadist group.
Assad's office said the government would redouble its efforts against rebel groups after the US strike -- the first direct military action by Washington against the Damascus regime.
"This aggression has increased Syria's determination to strike these terrorist agents, to continue crushing them and to speed up the pace of work on this, wherever they are on Syrian territory," it said.
"The disgraceful act of targeting a sovereign state's airport demonstrates once again that different administrations do not change deeper policies."
The massive strike -- US President Donald Trump's biggest military decision since taking office -- marked a dramatic escalation in American involvement in Syria's six-year civil war.
It followed days of outrage at images of dead children and victims suffering convulsions from the suspected sarin gas attack on the rebel-held town of Khan Sheikhun.